Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment by promoting tumor cell proliferation, drug resistance, invasion, and metastasis through the secretion of proteins such as TGF-β, HGF, and IL-6. Additionally, CAF is involved in various pathways that support tumor development, such as blood and lymphatic vessel formation, extracellular matrix remodeling, immunosuppression, and epithelial-mesenchymal transition of tumor cells. As a result, targeting CAF has become a promising approach in the development of anticancer drugs.